FABRICATION, CHARACTERIZATION AND ANTIBACTERIAL PROPERTIES OF GELATIN/NA-ALGINATE COMPOSITE FILM CONTAINING CURCUMIN/IRON NANOPARTICLES

In this work, gel/na-alginate films containing curcumin were made using the straightforward procedure of mixing gel/na-alg solutions, followed by linking with glutaraldehyde solution. Glutaraldehyde was injected into the film solutions made at various proportions (A: G=25:75, 50:50, 75:25 and 10:90), and the resulting film’s mechanical, thermal, and swelling characteristics were evaluated. Gelatin and Sodium alginate were combined in a biocompatible wound dressing material that was effectively used in the biomedical areas. Several biochemical and molecular waterfalls, such as swelling, tissue growth, and the remodeling stage, identify the wound healing procedure. The natural bioactive ingredient curcumin, an anti-inflammatory, antioxidant, and tissue regeneration factor, was introduced in the film. Also, iron oxide nanoparticles are very appealing due to their non-poisonous properties in biomedical applications of biological systems. Composite film loaded with curcumin and iron nanoparticles using biopolymers of gel/na-alg with the help of a crosslinker (glutaraldehyde). The synthesized films are characterized by numerous techniques, including XRD, FTIR, SEM, and Thermo gravimetric analysis (TGA). The chemical studies also carried out were the welling study. Curcumin extract and iron nanoparticles are characterized by ultraviolet (UV)-visible spectroscopy. The morphological investigation confirmed the genesis and creation of the film. Escherichia coli bacteria were used to investigate the efficacy of GEL/Na-Alg films loaded with curcumin extract and iron nanoparticles as antibacterial agents (E. coli bacteria). As a result, an all-natural alginate-gelatin-curcumin-iron nanoparticles composite may be investigated as a foundation for effective and affordable wound healing.