MODIFICATION AND EVALUATION OF MODIFIED FORMULATIONS OF ORAL HEALTH AND HYGIENE BY UTILIZATION OF THE PARTS OF PHYLLANTHUS RETICULATES

Phyllanthus reticulatus Poir., of family Euphorbiaceae was an important therapeutic plant in the traditional medicine, and gaining favour in modern medicine as a plant with varied pharmacological properties. This sericeous shrub is also known as Kirganelia reticulata is widely distributed in India, Thailand, China, Africa and Malaysia. Mouthwash, gargles, mouth spray were formulations were modified using leaves, fruit and stem extract of the plant. The extract of Phyllanthus reticulatus Poir., were studied to have antibacterial, antimicrobial as well as anti-inflammatory activity. Various qualitative tests were performed to authenticate the plant and its property. Presences of alkaloids, phenolic compounds, tannins, coumarins in extract were indicated by the phytoconstituents and UV spectral tests. The extract was found to be stable at acidic state. Fruit extract of Phyllanthus reticulates contain anthocyanin (Delphinidin) which ere detected by TLC and HPTLC. The modified formulations showed good sensitivity towards strains of S. mutans in comparision with marketed product containing Chlorhexidine. The accelerated study proves that the modified products are stable at room temperature. Hence a valuable insight of understanding the Phyllanthus reticulatus typical shrub and even the fruits were used in mouthwash, gargle and mouths pray formulation. Even though the results shows safety and efficacy of formulation, the study was short term so long term study is required with large scale of the formulations as the one strain of the oral bacterial strain was used.