NOVEL SYNTHESIS OF OXADIAZOLE DERIVATIVES WITH PYRIMIDINE MOIETY
AbstractA series of different 6-Methyl – 4- aryl -5 – (5-aryl -1,3,4-oxadiazole-2-yl ) -1,2,3,4-tetrahydro pyrimidin-2- (1H) – one / thione ( IIIa-g) have been synthesised fromEthyl – 6- methyl- 2- oxo / thioxo – 4-substituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (Ia-g) followed by reaction with hydrazine hydrate in ethanol gave 6 – methyl-2-oxo / thioxo – 4 -substituted phenyl – 1,2,3,4-tetrahydro pyrimidine-5-carbo hydrazide (IIa-g) by means of Microwave irradiation for 2-4 mins and giving excellent yield in short reaction time, are notable advantages of this method. The structure elucidations of all the synthesised compounds have been accomplished by elemental analysis, IR, NMR and Mass spectroscopic method.
Article Information
41
4416-4421
366KB
1037
English
IJPSR
Shubhangi P. Waghamale and Pravina B. Piste*
P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science, Satara- 415 001, Maharashtra, India
ppiste321@gmail.com
14 June, 2013
16 July, 2013
22 October, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(11).4416-21
01 November, 2013
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