FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF METOPROLOL SUCCINATE TO IMPROVE PATIENT COMPLIANCE AND BIOAVAILABILITY

Metoprolol Succinate is an effective cardio-selective beta-1 blocker, that is used to treat acute disorders such as hypertension and cardiac diseases such as angina pectoris and cardiac heart failure (CHF). Oral route is the most convenient route for introducing different kind of drugs as it is preferred as the safest, cheaper & easiest route. Newly, researchers developed fast disintegrating tablets (FDT) with improved patient compliance. The main motto of this fast-disintegrating sublingual tablet is that is placed under the tongue &disintegrates rapidly within a short span of time in the presence of saliva. First-pass metabolism can be avoided by the sublingual route &the drug directly reaches into the systemic circulation. FDTs manage to overcome from hindrances such as dysphagia in pediatric, geriatric & unconscious patients. The FDTs were formed by different conc. Of super disintegrating agents such as crospovidone by direct compression method. The compatibility study of API & other excipients was studied & determined by DSC & FTIR techniques. The formulation was evaluated by studying various parameters such as solubility, M.P, ph, appearance, thicknesses, hardness, friability, weight variation, wetting time, water absorption, dissolution, disintegration & in-vitro drug release. Micromeritics properties of API & other excipients were studied & determined by various parameters such as bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. Optimized batch F5 containing a quantity of crospovidone 10mg & MCC 30mg was found to be the most stable formulation.