DISSOLUTION ENHANCEMENT OF ROSUVASTATIN CALCIUM BY USING VARIOUS GENERATIONS OF HYDROPHILIC POLYMERS: A COMPARATIVE STUDY

Oral administration is the preferred route of drug administration owing to its convenience, patient compliance, and cost-effectiveness. The study aspired to augment the solubility and dissolution rate of Rosuvastatin calcium (RST) by using the solid dispersion (SD) technique with various generations of hydrophilic polymers. Hot melt and solvent evaporation methods were employed to prepare SD using various hydrophilic carriers such as Urea, PEG-6000, Poloxamer-F127 and β-cyclodextrin (β-CD). The prepared SD was evaluated and the optimized formulation was subjected to tablet formulation by direct compression method and a quality control test was performed. After screening all the hydrophilic polymers, SD was prepared by using β-CD shows a remarkable increase in solubility and dissolution. Among the ratios 1:1, 1:5 and 1:7, SD with 1:5 showed increased solubility and maximum drug release and shows good surface characteristics were identified by SEM analysis. Finally, the prepared core tablet CF2 was found to have better dissolution efficiency of 96.34% drug release at 60mins, when compared with CF1 (81.46%) and the Marketed tablet (85.44%). The result suggested that the optimized formulation of SD with the hydrophilic carrier is an effective tool in the predominant increase in solubility and dissolution rate, thereby enhancing the solubility and bioavailability.