EFFICACY AND SAFETY OF ORAL TRANEXAMIC ACID WITH GLYCOLIC ACID 35% SOLUTIONVS ORAL TRANEXAMIC ACID WITH MODIFIED JESSNER’S SOLUTION IN TREATING MELASMA: A COMPARATIVE STUDY

Background: Melasma is a frequent hyper pigmentary disorder characterized by the presence of brown to grey patches on the face. For melasma management, various modalities available that includes kojic acid, azelaic acid, Kligman’s regimen, peels like glycolic acid, trichloroacetic acid (TCA), jessner’s etc are in use but unsatisfactory results, recently tranexamic acid (TA) has added to treatment armamentarium for resistant melasma. Objective: To know the efficacy of oral tranexamic acid with glycolic acid 35% peel verses oral tranexamic acid with modified jessner’s peel in treating melasma. Materials and Methods: Present study includes 60 patients with melasma, divided into group A and group B. Group A treated with glycolic acid peel and oral TA and group B treated with modified jessners peel with oral TA. Severity of melasma was assessed after 4th, 8th and 12th weeks after combination treatment using mMASI score. Results: Present study mean age affected 43.2+/-5.4 years, predominantly affected were females (75%). There is a significant difference in the severity of melasma between both groups at the end of 4th week (group A 12.2+/-1.4, group B 13.5+/-2.2), at the end of 8th the week (group A 10.4+/-2.1, group B 12.1+/-1.8) and at the end of 12 weeks (group A 8.9+/-2.4, group B 10.2+/-3.1) according to mMASI score. Conclusion: Oral tranexamic acid with glycolic acid 35% peel proved to be superior in efficacy and safety in treating melasma compared to oral tranexamic acid with modified jessner’s peel.