OPTIMIZATION AND DEVELOPMENT OF TOPICAL METAL ION – CONTAINING ANTIBACTERIAL CREAM AND GELS
AbstractNormally and often skin infections present therapeutic challenges to practitioners and researchers due to the growing concern regarding multi-drug resistant bacterial, Viral, and Fungi Strains. The Antibacterial properties of zinc sulphate and copper sulfate are well known and have been investigated for many previous years. However, the synergistic effect between both metal ions as antibacterial ingredients has not been evaluated in topical formulations like gels and creams. The aim of the present study to formulate cream and gels containing zinc and copper individually or in combination and evaluate the in-vitro antibacterial activity of these metal ion in the formulation. Zinc sulfate and copper sulfate had a strong synergistic antibacterial activity in cream and gels. By evaluating the various parameters such as pH, Spreadability, viscosity, and antibacterial properties it is confirm that the metal gel and cream enhance the antibacterial activity. This study evaluated and confirmed the synergistic in-vitro antibacterial effect of copper sulfate and zinc sulfate in cream and gels.
Article Information
42
971-978
602 KB
224
English
IJPSR
Ankit Singh Chauhan * and Ashvani Kumar
Institute of Pharmaceutical Sciences and Research, Unnao, Uttar Pradesh, India.
ankitsinghchauhan1893@gmail.com
29 July 2023
22 November 2023
27 November 2023
10.13040/IJPSR.0975-8232.15(3).971-98
01 March 2024
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