CHRONOPHARMACOLOGICAL ASPECT ON IMPAIRMENT OF LIVER CIRCADIAN CLOCK AND HEPATIC DYSFUNCTION: A REVIEW
AbstractHepatitis B, Diabetes, Alcoholic and Non-alcoholic Fatty Liver Disease, Cholangiocarcinoma, Cholangioleiomyopathies, and other risk factors for hepatic illness are all becoming more harmful nowadays. In animals, the dysfunction of melatonin levels and an unbalanced circadian rhythm can control physiological processes and cellular mechanisms during periods of rest and activity. The Suprachiasmatic Nucleus (SCN) in the Hypothalamus of the Brain and Melatonin production in the pineal gland control circadian rhythms and clock gene expressions. The main purpose of the study is to summarise the most recent research on the molecular mechanisms underlying Circadian Rhythm, including the core clock genes and melatonin release, and their relationship to chronic liver diseases. Also covered were the future methods for studying Circadian Rhythm’s Chronopharmacological Aspects for the Treatment of Hepatic Diseases.
Article Information
2
1006-1014
734 KB
549
English
IJPSR
Lopamudra Saha, Debarati Kar and Dipanjan Mandal *
Department of Pharmacy, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Road, Sodepur, Kolkata, West Bengal, India.
dipanjan.mondal@gnipst.ac.in
14 August 2023
10 February 2024
20 March 2024
10.13040/IJPSR.0975-8232.15(4).1006-14
01 April 2024
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