BIBLIOMETRIC ANALYSIS OF LIQUID CRYSTALLINE NANOPARTICLES IN TRANSDERMAL DRUG DELIVERY AND THERAPEUTICS ADVANCES
AbstractThis systematic review provides a comprehensive overview of recent advancements in liquid crystalline nanoparticles (LCNs) utilized for transdermal drug delivery systems. Recent literature indicates a surge in research emphasizing lipid carriers derived from glyceryl monooleate and monoolein. The inherent nanostructure of LCNs offers superior solubilization capacity for bioactive molecules and controlled release mechanisms. This study underscores the potential of the cubic phase in LCNs as an innovative avenue for sustainable Transdermal Drug Delivery Systems (TDDS). Recent studies highlight the growing interest in cubosomes and hexosomes. Critical analysis necessitates further exploration into the therapeutic efficacy of Alpha lipoic acid cubosomes for anti-wrinkle applications, and the viability of hexagonal phase nano dispersions for in vivo peptide and siRNA delivery. A bibliometric assessment points out China as the leading contributor to LCN-centric publications. To summarize, LCNs are poised as potent TDDS, warranting future exploration in live skin imaging and immunological evaluations in animal model studiesproperties thus increasing residence time of drug with better patient compliance.
Article Information
9
1065-1085
1280 KB
207
English
IJPSR
Rupali Sharma *, Shekhar Sharma, Arun Mittal, Shabnam Thakur, Preeti Gupta, Anima Pandey and Satish Sardana
Amity Institute of Pharmacy, Amity University Haryana, Manesar, Gurgaon, Haryana, India.
rsharma9@ggn.amity.edu
16 August 2023
14 December 2023
30 December 2023
10.13040/IJPSR.0975-8232.15(4).1065-85
01 April 2024
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