FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF TIZANIDINE HYDROCHLORIDE USING COMBINATION OF POLYMERS
AbstractThe present study was carried out with an objective of formulation and evaluation of effervescent floating tablets of Tizanidine hydrochloride using combination of polymers. The floating tablets were prepared using HPMC and Tara gum as a combination of polymers. The tablet was prepared by direct compression method. The effect of polymer concentration was evaluated for gastroretention and sustained release action. Effervescence was produced by using sodium bicarbonate and citric acid which helps in reduction in floating lag time. The effect of polymer concentration on drug release and gastroretension has also been investigated. The results of in-vitro dissolution study shows that the drug formulation containing HPMC K15 M and Tara gum gives sustained action till 15 hr. Tara gum act as a sustained release polymer it sustains the dissolution of formulation by modifying the rheology of matrix. it is inert and non-toxic material. The formulation shows zero order kinetics. The matrix of formulation shows non-fickian diffusion. The present study shows that formulation gives sustained release action with muscle relaxant property till 15 hrs.
Article Information
16
1147-1156
819 KB
234
English
IJPSR
Shikha Yadav *, Ashish Rathore, Kirti Malviya, Sapna Malviya and Anil Kharia
Indore and Modern Institute of Pharmaceutical Sciences, Indore, Madhya Pradesh, India.
anamika.mips@gmail.com
03 September 2023
19 November 2023
30 December 2023
10.13040/IJPSR.0975-8232.15(4).1147-56
01 April 2024
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