FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLET OF LORATADINE BYUSINISABGOL MUCILAGE

Aim and Objective: The main aim of the research work is to formulate and evaluate fast disintegrating tablets of Loratadine by incorporating Ispaghula Mucilage as a Superdisintegrant. Materials and Methods: Tablets were produced utilizing the direct compression technique, incorporating three distinct synthetic superdisintegrants and a natural superdisintegrant (Ispaghula mucilage) at varying concentrations. The primary objective was to reduce disintegration time and enhance the bioavailability of Loratadine. Result: The pre-compression characteristics suggested that the compressibility and flow qualities were favourable. After compression, the tablets exhibited acceptable values for hardness (ranging from 3.4 ± 0.1 to 3.5 ± 0.1 kg/cm2), wetting time (ranging from 15.3 ± 0.5 to 45.6 ± 1.5 seconds), and water absorption ratio, all well within the specified limits. Given that the tablets are meant for oral disintegration, our primary focus was on in-vitro dissolution studies and disintegration time. Among all the formulations, F12 shows shortest disintegration time, merely 8 seconds, and the highest cumulative percent of drug release, reaching 98.67%, to its content of 30mg of Ispaghula mucilage. The accelerated stability test, conducted following the ICH guidelines, demonstrated the stability of the optimized F12 formulation at Relative humidity of 75%+5% and temperature of 40^oC+2^oC and were recorded throughout three months duration. Conclusion: Ispaghula mucilage proved to be the optimized formulation. It exhibited the fastest disintegration time, highest drug release, and favorable flow properties, making it a promising choice for the development of Fast disintegrating tablets of Loratadine.