LOCUST BEAN GUM: A PROMISING MATERIAL IN ORAL DRUG DELIVERY SYSTEM

The increasing demand for natural polymers has fuelled substantial investment in research and development within the pharmaceutical and biotech sectors. Natural polymers, lauded for their biocompatibility, biodegradability, and safety, offer versatile advantages and among these, polysaccharides and proteins stand out. One class of natural polymers, gums, obtained primarily from plants, is gaining prominence in pharmaceuticals, biotechnology, and food industries. Notable examples include Xanthan gum, Guar gum, Locust bean gum (LBG), and Tara gum, all sharing the galactomannan compound at their core. LBG exhibits a range of physical and chemical properties that make it a valuable candidate for drug delivery systems. This natural biopolymer, with its unique characteristics, presents a compelling case for incorporation into oral drug delivery systems. The chemical composition of LBG makes it well-suited for interaction with other natural polymers. This interaction can lead to the development of novel drug delivery systems with controlled-release, improved solubility, and enhanced bioavailability. LBG’s compatibility with various natural polymers offers a wide array of possibilities for formulation enhancement. Pharmaceutical applications of LBG encompass matrix-forming tablets, orodispersible tablets, enhanced drug solubility, mucoadhesive and buccal drug delivery systems, microparticles, and nanoparticles. The scope of LBG is promising, with potential applications in food, pharmaceuticals, cosmetics, and sustainable packaging solutions. In conclusion, the integration of LBG into oral drug delivery systems exemplifies its versatility and potential to transform pharmaceutical formulations. LBG aligns with the growing preference for natural and effective solutions across multiple industries, offering an exciting avenue for future research and development.