ATTENUATION OF NEPHROTOXICITY INDUCED WITH CISPLATIN IN HEK 293 CELL LINES BY SAGADEVI NEI
AbstractSagadevi nei is a Siddha polyherbal formulation indicated for Neerkattu and Neersurukku. The main ingredient of the formulation is Vernonia cinerea, belonging to the family Fabaceae, which has been proven scientifically to exhibit renal tubular regrowth. Based on Literature, each ingredient of the mixture has nephroprotective, diuretic, antioxidant, and anti-inflammatory properties. Cisplatin is a metallic compound antineoplastic drug with a known side effect of renal damage. The present study aims to elucidate the attenuative effect of Sagadevi Nei against Nephrotoxicity. MTT assay is a sensitive and reliable indicator of cellular metabolic activity. This study is done in-vitro by MTT assay in Human Embryonic Kidney (HEK) 293 cell lines. The toxicity was induced by cisplatin and the amount of cell damage was calculated. The Nephroprotective activity assessed by MTT Assay against cisplatin-treated HEK293 Cell lines co-treated with Sagadevi Nei showed an increase in the percentage of cell viability from 49.82% to 67.87% in a dose-dependent manner.
Article Information
16
2036-2040
704 KB
300
English
IJPSR
B. Abarna, M. Sathyarathish, V. Manjari * and K. Kalaivanan
Department of Nanju Maruthuvam, National Institute of Siddha, Chennai, Tamil Nadu, India.
drmanjarimd@gmail.com
04 January 2024
16 February 2024
16 April 2024
10.13040/IJPSR.0975-8232.15(7).2036-40
01 July 2024
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