THE CONCENTRATION/RESPONSE FUNCTION BEHAVIORSOF NONCALORIC AND CALORIC SWEETENERS
AbstractSweeteners are generally described in terms of their sweetness potencies relative to sucrose references. And, while caloric sweeteners have been found to have potencies invariant with sucrose reference concentration, noncaloric sweeteners decrease in potency as sucrose reference concentration increases. In this study, we develop methodology to determine the Concentration/Response functions for 9 (Omit “the”) noncaloric and 2 caloric sweeteners in water at room temperature. Two-Alternative Forced Choice methodology with a panel of 80 subjects was used to determine is sweet concentrations for these 11 sweeteners and multiple concentrations of sucrose. We found that the is sweetness data for all 8 of the high-potency noncaloric sweeteners are well modeled by the Law of Mass Action R = (Rm X C)/(Kd + C), where R is Response in % Sucrose Equivalents, Rm is Maximal Response in % Sucrose Equivalents, C is the sweetener Concentration in mg/L and Kd is the Concentration in mg/L resulting in Half-Maximal Response. We also found that the is sweetness data for the 2 caloric sweeteners Glucose and Fructose as well as the noncaloric sweetener Erythritol are well modeled by the linear function R = mC + b where m is the sweetener potency. This study enables an improved understanding of the bio-rationale for the well-known phenomenon of Sweetness Linger for high-potency noncaloric sweeteners. The Kd values determined for these sweeteners enable calculation of the half-lives for Sweetener Receptor / Sweetener dissociation. Our results make it clear that prolonged residence time on the Sweetener Receptor cannot be the bio-rationale for Sweetness Linger.
Article Information
12
2289-2295
518 KB
114
English
IJPSR
Grant E. DuBois, Rafael I. San Miguel, B. Thomas Carr, Karen Wilkens, Allison Bechman and Indra Prakash *
Flavor & Ingredient Research, The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, GA 30313, USA.
iprakash@coca-cola.com
12 February 2024
20 March 2024
19 April 2024
10.13040/IJPSR.0975-8232.15(8).2289-95
01 August 2024