ANTIOXIDANT AND ANTITUMOR EFFECTS OF MORINGA OLEIFERA LAM AGAINST EHRLICH’S ASCITES CARCINOMA BEARING MICE

Objectives: Moringa oleifera has enormous attention as the ‘natural nutrition of the tropics and an essential food commodity. Antioxidants important in deactivating free radicals having damaging role on biological cells. Polyphenolic compounds are the most prevalent antioxidants seen in plants. Present study aims to evaluate the antioxidant and antitumor effect of ethanolic leaf extract of Moringa oleifera (ELMO) against Ehrlich’s ascites carcinoma bearing Swiss albino mice. Materials and Methods: 500 mg/kg body weight of ELMO was administered once in a day about 15 days after 24hrs of tumour inoculation. In mice treated with ELMO we observed decreased body weight, abdominal circumference and tumour volume, when compared to Ehrlich’s ascites carcinoma control mice. We also observed in mice Treatment with ELMO decreased levels of lipid peroxidation (LPO) and increased levels of (GSH), and superoxide dismutase (SOD). Results: Mice treated with 500mg/kg body weight of ELMO have shown a significant decrease in both the protective and curative group of body weight, tumour volume, and abdominal circumference compared to the Ehrlich’s ascites carcinoma tumour group. The levels of lipid peroxidation, GSH, and superoxide dismutase also altered. Discussion and Conclusion: The present study demonstrates that the ethanolic leaves extract of Moringa oleifera increased the life span of Ehrlich’s ascites carcinoma tumour-bearing mice and decreased lipid peroxidation. These parameters suggest that the ethanolic leaves extract of Moringa oleifera exhibits potential antioxidant and antitumor effects.