LOCAL ANAESTHETIC ACTIVITY STUDIES OF THE EXOTIC PLANT SPECIES, CROTON BONPLANDIANUM BAILL
AbstractPharmaceutical corporations have been heavily involved in the development of natural plant-based goods to create the most economical and cost-effective medicines for the underprivileged in recent years. Plants are abundant natural product suppliers. One of such natural sources having great medicinal value is Croton bonplandianum, commonly known as ‘bantulasi’; Family: Euphorbiaceae. Because Croton bonplandianum is an alien plant species, the presence of alkaloids, flavonoids, saponins, steroids, resins, phenols, and rutin gives rise to its very useful medicinal value. It is used to treat skin problems, wounds, and high blood pressure. Three distinct guinea pig and frog experimental models were used in this investigation to screen the Croton bonplandianum extracts. The extract at dilutions 1:10, 1:50 and 1:100 showed the anesthetic activity in a dose-dependent manner in contrast to the typical medication xylocaine (0.2%). The techniques include lumbar plexus anesthesia, nerve block anesthesia, frog muscle twitch, guinea pig infiltration anesthesia, and surface anesthesia in rabbits. It was concluded that extracts of Croton bonplandianum possess local anesthetic activity.
Article Information
26
3123-3128
555 KB
98
English
IJPSR
Subhas Chandra Maity *, Padmanath Pegu, Subhasis Maity, Debaprotim Dasgupta and Mrinmoy Nag
NSHM Institute of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata, West Bengal, India.
subhaschandramaity70@gmail.com
21 April 2024
05 September 2024
11 September 2024
10.13040/IJPSR.0975-8232.15(10).3123-28
01 October 2024
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