STUDIES ON THE METHANOL EXTRACT OF LEPIDAGATHIS FASCICULATA AND ITS FRACTIONS FOR THE TREATMENT OF DIABETES AND FOR IN-VITRO ENZYME INHIBITION
AbstractThe present research focused to decide the premier dosage of methanol extract of Lepidagathis fasciculata whole plant extract and examining the α-amylase and α-glucosidase inhibitors of diabetic rats utilized to execute stronger command of hyperglycemia allowed for the blood glucose to be lowered in these animals. In streptozotocin-induced rats, the anti-hyperglycemic effects of oral administration of various doses of methanol extract revealed that the highest dose considerably lowered blood glucose levels analyzed to further dosage. Additionally, ethyl acetate and n-butanol fractions showed a better anti hyperglycaemic impact than n-hexane and chloroform fractions, according to the results of the repeated administration of methanol fractions. In addition, the in-vitro studies results demonstrated that the consequences of methanol extract and its fraction onα-amylase and α-glucosidase enzyme exercises could be controlled with low concentrations of ethyl acetate and n-butanol measured to different fractions and Acarbose, which was utilized as a positive control. These results suggested that the presence of polyphenolic active ingredients allowed the mobile coarse extract (methanol) and its vital fractions (ethyl acetate and n-butanol) to significantly lower blood sugar levels. The discovery of novel drugs for the treatment of diabetes and its consequences may be facilitated by the separation of the active components of Lepidagathis fasciculata.
Article Information
11
3228-3234
575 KB
4
English
IJPSR
Sravanthi Porika * and Yellu Narsimha Reddy
Department of Pharmacology & Toxicology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.
sravanthy.thirunahari@gmail.com
27 May 2024
21 June 2024
17 July 2024
10.13040/IJPSR.0975-8232.15(11).3228-34
01 November 2024