PREPARATION AND EVALUATION OF INSULIN MICROPARTICLES BASED GEL FROM NATURAL SOURCES FOR NASAL DELIVERY
AbstractIonotropic gelation, a characteristic property, has become one of the easy, simple and mild ways of encapsulating variety of drugs, enzymes, and proteins, prepared by various Polysaccharides. The externally crosslinked beads with calcium chloride and zinc chloride were suitable for water soluble and low molecular weight drugs. Insulin, encapsulated in a calcium pectinate gel / Sodium alginate bead by dispersing the insulin and core cross linking agent in a solution of pectin, beads are prepared by spraying the dispersion in calcium chloride by Inotropic gelation. The purpose of present research work was to study effect of different concentration of sodium alginate and pectin solution on the drug entrapment, drug release and stability of Insulin. Insulin is a high molecular weight drug, widely used to treat diabetic patients. The beads were prepared with factorial design and evaluated for, entrapment efficiency, stability and bioadhesivity. The formulated gel was evaluated for administration in the nasal cavity for treatment of diabetics.
Article Information
20
3581-3591
1008 KB
22
English
IJPSR
V. Prabakaran * and N. V. Satheesh Madhav
Novitium Pharma LLC, East Windsor, New Jersey - 08520, USA.
prabusuresh@yahoo.co.in
08 January 2024
10 November 2024
12 November 2024
10.13040/IJPSR.0975-8232.15(12).3581-91
01 December 2024
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