EXPLORING THE ANTIDEPRESSANT POTENTIAL OF CURCUMA LONGA RHIZOME: AN EXPERIMENTAL STUDY WITH ALBINO RATS
AbstractBackground- Depression is a mental health condition with various symptoms including low energy, disrupted sleep, and suicidal ideation. Antidepressants have negative side effects and can cause drug interactions. Curcuma longa, a herbal extract, has shown potential in treating depression due to its antioxidant and anti-inflammatory properties. A study is planned to evaluate its antidepressant activity. Aim and Objective: To study the anti-depressant activity of Curcuma longa rhizome using animal models and to find out its mechanism of action. Materials and Methods: Ethanolic extraction using Soxhlet apparatus, forced swimming test, open field behavior. Results: Curcuma longa rhizome possess antidepressant property. Conclusion: The study investigated the effectiveness of Curcuma longa rhizome in treating depression. Two doses of the ethanol extract were tested in mice, and their behaviour was assessed in various tests. The extract showed antidepressant action by increasing serotonin, norepinephrine and dopamine levels in the brain and antagonizing the GABA receptor. No sleep-promoting compounds were found in the extract.
Article Information
28
3643-3651
1961 KB
21
English
IJPSR
Ahmar Hasan
Department of Pharmacology, Jawaharlal Nehru Medical College; Hospital, A.M.U, Aligarh, Uttar Pradesh, India.
ahmar.hasan5@gmail.com
12 July 2024
27 August 2024
25 October 2024
10.13040/IJPSR.0975-8232.15(12).3643-51
01 December 2024
Download