IN-SILICO ANALYSIS OF PHYTOCHEMICALS FROM GINKGO BILOBA AND AEGLE MARMELOS AGAINST ALLERGIC CONJUNCTIVITIS

Allergic conjunctivitis (AC) is a prevalent ocular condition characterized by inflammation of the conjunctiva due to allergen exposure, resulting in itching, redness, and discomfort. Traditional medicinal plants such as Ginkgo biloba and Aegle marmelos have been recognized for their potential anti-inflammatory and anti-allergic properties. In this study, we conducted an in-silico analysis to explore the therapeutic potential of phytochemicals derived from Ginkgo biloba and Aegle marmelos against AC. First, we compiled a list of phytochemicals in Ginkgo biloba and Aegle marmelos, focusing on compounds known for their anti-inflammatory and immunomodulatory activities. Molecular docking studies were performed to investigate the binding interactions between these phytochemicals and key proteins implicated in the pathogenesis of AC, including histamine receptors, inflammatory cytokines, and enzymes involved in the allergic response. Virtual screening techniques were employed to identify potential lead compounds with high binding affinities and favorable pharmacokinetic properties. Additionally, ADME/T properties were predicted to assess the bioavailability, metabolic stability, and potential toxicity of the selected phytochemicals. In-silico findings suggest that certain phytochemicals from Ginkgo biloba and Aegle marmelos exhibit promising anti-allergic and anti-inflammatory activities, making them attractive candidates for further experimental validation and development as potential therapeutic agents for the management of allergic conjunctivitis. These computational insights contribute to the rational design and discovery of novel phytochemical-based treatments for AC, offering new avenues for drug development in ocular allergy management.