A SYSTEMATIC REVIEW ON MUCOADHESION A NOVEL DRUG DELIVERY SYSTEM
AbstractThe phenomenon known as mucoadhesion is characterized by interfacial molecular attractive forces between a natural or synthetic polymer and the surface of a biological membrane. This allows the polymer to stick to the membrane’s surface for a prolonged period of time. The idea of mucoadhesion has garnered significant attention in many pharmaceutics sectors during the past forty years. The mucoadhesive buccal drug delivery system has numerous benefits that make it a unique drug delivery method for both local and systemic administration of different medications. The primary benefit of using this route for medication administration is that it avoids the initial metabolic stage of many methods circumvents the first pass metabolism of a number of medications that are susceptible to their first pass metabolism in the liver. Mucoadhesive drug delivery system contacts with mucus layer and generally increases the retention time of the dosage form at the specific site of absorption. The structural characteristics of the mucosa, the mechanism of mucoadhesion, various theories of mucoadhesion, are briefly discussed in this review to provide a brief overview of mucosal drug delivery.
Article Information
3
601-608
521 KB
162
English
IJPSR
Moonmoon Banerjee, Shweta Kumari * and Shruti Rathore
Department of Pharmaceutics, LCIT School of Pharmacy, Bilaspur, Chhattisgarh, India.
Shweta.kumari@lcit.edu.in
13 September 2024
28 October 2024
05 November 2024
10.13040/IJPSR.0975-8232.16(3).601-08
01 March 2025
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