DESIGN, SYNTHESIS AND EVALUATION OF SOME NEW ISOXAZOLES, CYANO-PYRIDINES AND 1, 5 BENZOTHIAZEPINES AS ANTIMICROBIAL AGENTS
AbstractThe title compounds (7a-f), (8a-f) and (9a-f) have been prepared from chalcones (6a-f) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles (7a-f) and cyanopyridines (8a-f) respectively. Chalcones (6a-f) on condensation with 2-amino thiophenol in the presence of glacial acetic acid give benzothiazepines (9a-f). Structures of newly synthesised compounds were established on the basis of their elemental analysis, IR and 1H NMR. All the synthesised compounds have been screened for their antimicrobial activity
Article Information
27
4671-4675
330KB
1090
English
IJPSR
A. Solankee* and R. Patel
Department of Chemistry, B. K. M. Science College, Valsad-396001, Gujarat, India
dranjani_solankee@yahoo.com
26 July, 2013
11 September, 2013
26 November, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4671-75
01 December 2013
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