A UNIQUE POLYHERBAL FORMULATION FOR COGNITIVE ENHANCEMENT AND MENTAL HEALTH SUPPORT

In an increasingly fast-paced world, the rising prevalence of anxiety and mental health disorders highlights the critical need to preserve cognitive well-being. While mental illnesses often result from complex biological, psychological, and environmental interactions, their precise origins remain elusive. Conventional medicine offers various treatments, but alternative approaches, like nervine tonics, are garnering attention for their natural, therapeutic potential in supporting the nervous system and promoting relaxation. This study introduces Neuragreen, a novel polyherbal nervine tonic designed to enhance blood circulation, regenerate nerve cells, and exhibit potent nootropic, anti-Alzheimer, anti-depressant, and antioxidant effects. The formulation blends powerful herbal ingredients, including Ginkgo biloba, Centella asiatica, Bacopa monnieri, Withania somnifera, Mucuna pruriens, Pueraria tuberosa, Convolvulus pluricaulis, Celastrus paniculatus, Beta carotene, and B-complex vitamins. A multidisciplinary approach was employed, utilizing LCMS, UV-Visible, and FTIR spectroscopy, along with antioxidant assays and molecular docking. LCMS identified diverse bioactive compounds, while UV-Visible spectroscopy revealed the presence of flavonoids, terpenes, and alkaloids. FTIR confirmed the presence of polyphenolic compounds with antioxidant potential, and terpenoids were also detected. Antioxidant assays showed strong free radical scavenging activity with IC₅₀ values of 7.3 µg/mL for DPPH and 14.9 µg/mL for SOD. The analytical findings emphasized the formulation’s richness in terpenoids, flavonoids, saponins, and alkaloids. Molecular docking studies further supported the formulation’s potential nervine activity, identifying nine key phytochemicals with neuroprotective effects, potentially reducing depression and enhancing memory. This research highlights Neuragreen as a promising polyherbal formulation with significant therapeutic potential for cognitive and mental health support.