TO REPORT THE PHYTOCHEMISTRY & PHARMACOLOGICAL (ANTIPYRETIC ACTIVITY) POTENTIAL OF QUERCETIN & CRUDE EXTRACT OBTAINED FROM CYNODON DACTYLON: AN INDIAN DOAB GRASS

The research rigorously investigates the bioactive potential of Cynodon dactylon, specifically focusing on its antipyretic properties attributed to quercetin, a flavonoid compound. Cynodon dactylon, a perennial grass, has been traditionally used in various medicinal practices, prompting scientific inquiry into its pharmacological benefits. The study involved meticulous extraction and isolation of quercetin from Cynodon dactylon using advanced solvent extraction and chromatographic techniques. The purity and structure of the isolated compound were unequivocally confirmed through rigorous spectroscopic methods, including UV and NMR analyses, ensuring the absolute reliability of the isolated quercetin for subsequent pharmacological evaluations. An in vivo experimental model using pyrexia-induced rodents was employed to robustly assess the antipyretic activity of Cynodon dactylon extract and isolated quercetin, comparing their efficacy with standard antipyretic drugs. The results unequivocally indicated a significant reduction in elevated body temperature in the treated groups, conclusively demonstrating the remarkable effectiveness of Cynodon dactylon and its quercetin component in reducing fever. The study concludes that quercetin isolated from Cynodon dactylon exhibits notable antipyretic activity, unequivocally validating its traditional use in fever management. The findings conclusively demonstrate that quercetin is a highly promising candidate for developing natural fever-reducing agents. Moreover, this research emphatically underscores the crucial importance of exploring natural flora for bioactive compounds with therapeutic applications, advocating for further robust studies to elucidate the mechanisms underlying the antipyretic effects and to explore other pharmacological potentials of Cynodon dactylon.