EFFECT OF METHANOLIC EXTRACT OF PLUMERIA PUDICA JACQ. LEAVES AGAINST DMBA-INDUCED MAMMARY CARCINOMA IN RATS

Background: Breast cancer is the most occurring cancer in women and the second most reason for tumour related deaths in women. Chemoprevention, which involves employing dietary, natural, or synthetic items, has emerged as an intriguing strategy to deal with increase in Breast cancer cases. Plumeria pudica Jacq. is fast growing, having medium size and belongs to the family Apocynaceae. The high concentration of phenols and phenolic chemicals in P. Pudica suggests that it may be utilised to cure cancer. Materials and Methods: In present study, mammary carcinoma was induced in female wistar rats by intragastric (IG) administration of 7, 12-dimethylbenz[a] anthracene (DMBA) at a dose of 80mg/kg of body weight. Treatment of methanolic extract of plumeria pudica leaves (200mg/kg/BW, thrice a week) to breast tumor bearing rats was found to be effective against DMBA induced mammary carcinoma. Progression of mammary carcinoma associated with decrease in body weight, anaemia, leucocytopenia, elevated levels of tumorigenicity, increase in oxidative stress and increased Liver biomarker levels. Result: The study showed the ability of various phytoconstituents present in Plumeria pudica in enhancement of body weight, decrease in tumorigenic parameters, and restoration of haematological function with hepatoprotective effect. Conclusion: From overall study, we can say that the pre-treatment with Plumeria pudica has showed Chemopreventive effect in DMBA induced mammary carcinoma in rats. These findings demonstrate the preventive role of Plumeria pudica in DMBA induced mammary carcinoma in rats.