ANTIOXIDANT AND ANTI-INFLAMMATORY INSIGHTS OF PSEUDOPTEROGORGIA AUSTRALIENSIS COLLECTED FROM WEST COAST OF MUMBAI

The study investigates to find the antioxidant and anti-inflammatory properties of the crude extract of coral Pseudopterogorgia australiensis. Various assays were used to assess the biological activities of the crude extract. The antioxidant capacity was evaluated using DPPH, ABTS, and FRAP tests. The DPPH assay indicated a dose-dependent radical scavenging effect whereas the ABTS assay showed a significant inhibition of which is comparable to ascorbic acid. In the case of FRAP assay it confirmed that the antioxidant activity revealing a strong reducing power which was equivalent to Trolox. These results demonstrated that the crude extract of Pseudopterogorgia australiensis have strong potential to neutralize ROS and mitigate oxidative damage. The Anti-inflammatory activity was assessed through albumin denaturation, proteinase inhibitory activity, and heat-induced heamolysis. The albumin denaturation assay demonstrated moderate inhibition where as the proteinase inhibitory assay showed stronger inhibition which is comparable to diclofenac sodium.  In the case of heat-induced heamolysis it showed notable dose-dependent inhibition of protein denaturation which is comparable to the standard drug diclofenac sodium. From the above findings it underscores that crude extract of Pseudopterogorgia australiensis have strong potential to stabilize proteins and prevent their denaturation, positioning it as a promising candidate for anti-inflammatory  and cytotoxic activity thus it confirms that the crude extract of Pseudopterogorgia australiensis may be useful for therapeutic use in future.