PRE FORMULATION STUDY OF DEXKETOPROFEN TROMETAMOL

The research aims to do a pre-formulation study on powdered drug of Dexketoprofen Trometamol to know its physical, chemical and pysico-chemical properties. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are widely used for pain relief and inflammation reduction. Dexketoprofen Trometamol, a highly soluble Non-Steroidal Anti-Inflammatory Drug (NSAID) is tromethamine salt of Dexketoprofen (Active enantiomer of ketoprofen). It works by blocking the action of cyclo-oxygenase in the body. It is widely used for its analgesic and anti-inflammatory properties in the treatment of acute pain and musculoskeletal disorder and post operative pain. Dexketoprofen trometamol was subjected to microscopy, X-ray diffraction, UV-Visible spectroscopic analysis and FTIR spectroscopic analysis for its properties to study. The drug was also subjected to some physical examination to examine its organoleptic properties and subjected to some chemical analysis to determine its chemical properties. The research showed micro-sized particle size ranges (1-10µm) of drug with its hydrophilic nature and UV analysis of drug showed its λ max peak of absorbance at 259nm. The X-ray diffraction study and Melting point study showed that the powder has sharp melting point of 95-98oC that stated that the drug Dexketoprofen Trometamol have crystalline property. The partition coefficient of Dexketoprofen trometamol was found to be less than 1 that showed its highly hydrophilic nature. Due to trometamol salt form of the drug, it has higher onset of action. The Drug Dexketoprofen trometamol have shorter half life of about 100 minutes then it is used in frequent dosing, so it may be main field of research to use in controlled drug release and extended drug release.