SYSTEMATIC REVIEW: PHARMACOLOGICAL INTERACTIONS BETWEEN TRADITIONAL HERBAL MEDICINES AND MODERN PHARMACEUTICALS
AbstractIntroduction: The use of traditional herbal medicines in conjunction with modern pharmaceuticals is a growing trend. However, the concurrent use of these therapies can lead to significant pharmacological interactions affecting drug metabolism, efficacy and safety. Objective: This systematic review aims to provide a comprehensive overview of pharmacological interactions between traditional herbal medicines and modern pharmaceuticals, highlighting common interactions, elucidating underlying mechanisms and offering clinical recommendations. Methods: A systematic search was conducted in databases including PubMed, MEDLINE and the Cochrane Library for studies published up to July 2024. The review included clinical trials, observational studies, and reviews that examined interactions between herbal medicines and pharmaceuticals. Data were extracted and assessed for quality using the Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale. Results: Out of 3,245 records identified, 50 studies were included in the qualitative synthesis and 20 studies were included in the quantitative synthesis. Common herb-drug interactions were identified, such as St. John’s Wort with antidepressants and anticoagulants, Ginkgo Biloba with anticoagulants and anticonvulsants, and Ginseng with antidiabetic drugs and MAO inhibitors. These interactions often involve the modulation of cytochrome P450 enzymes and drug transporters, leading to altered pharmacokinetics and pharmacodynamics. Conclusion: Healthcare providers should be vigilant in monitoring for these interactions and adjusting treatment regimens accordingly to ensure patient safety. Further research is needed to develop comprehensive guidelines for the safe use of herbal medicines alongside conventional drugs.
Article Information
4
2163-2170
656 KB
37
English
IJPSR
Gaurav G. Kakasaniya *, Tejas M. Khakhkhar and Ridhdhi K. Hirapara
Department of Pharmacology, C. U. Shah Medical College & Hospital, Surendranagar, Gujarat, India.
gauravkakasaniya45@mail.com
03 February 2025
25 February 2025
27 February 2025
10.13040/IJPSR.0975-8232.16(8).2163-70
01 August 2025