CURRENT APPROACHES AND FUTURE TRENDS IN BILAYER TABLETS FOR OBESITY TREATMENT

Obesity is a complicated global health issue that necessitates novel therapeutic methods, as traditional treatments frequently fail to fulfill the different patient needs. Bilayer tablets, an advanced oral drug delivery technology, combine immediate-release and sustained-release layers in a single dosage form, allowing for quick symptom relief while maintaining stable plasma drug concentrations. This dual-action method improves therapeutic efficacy, lowers side effects, and increases patient adherence. Manufacturing advances, such as 3D printing and hot-melt extrusion, have improved the solubility, stability, and bioavailability of anti-obesity medications, underlining the promise of bilayer tablets to solve obesity-related issues. Additionally, adding artificial intelligence and precision medicine into bilayer tablet manufacturing allows for tailored drug combinations, optimal release profiles, and precise excipient selection. Emerging advances, such as biodegradable polymers and sensor-enabled systems, improve patient compliance, treatment monitoring, and sustainability. Despite its promise, difficulties like as manufacturing complexity, regulatory barriers, and high costs remain, necessitating additional research and innovation. Addressing these difficulties has the potential to unlock the full potential of bilayer tablets, revolutionizing obesity medicine and contributing to the management of the worldwide health epidemic.