IMPACT OF OCT-1 GENETIC VARIATION ON METFORMIN RESPONSE AND ITS GASTROINTESTINAL SIDE EFFECTS
AbstractMetformin used successfully by clinicians over the decades as a first-line treatment for hyperglycemia also it was a popular treatment for type-2 diabetes in those who are overweight, when diabetes is not controlled by a healthy diet and lifestyle changes. Genetic factors place an important role in modulating metformin efficacy and toxicity in which OCT- 1 was a major transporter of metformin so genetic polymorphism of OCT-1 largely influences the metformin response and toxicity. This review outlines the relation between OCT-1 variants and metformin induced gastrointestinal side effects with similar and varied results among studies and portrays the need for studies to prove the relation between metformin efficacy, gastrointestinal side effects, and genetic variation of OCT-1 so that future studies may contribute to personalized and safer metformin treatment.
Article Information
8
2501-2503
464 KB
4582
English
IJPSR
A. Mercy Jenifa * and B. Jayanthi
Department of Pharmacy Practice, Karapaga Vinayaga Institute for Pharmaceutical Sciences, Maduranthakam, Tamil Nadu, India.
mercyjenifa111@gmail.com
15 March 2025
25 April 2025
02 May 2025
10.13040/IJPSR.0975-8232.16(9).2501-03
01 September 2025
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