HEPATOPROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF MORINGA OLEIFERA LEAVES IN D- GALACTOSAMINE INDUCED HEPATITIS IN ALBINO RATS
AbstractThe study was conducted to evaluate the hepatoprotective effect of ethyl acetate extract of Moringa oleifera leaves in D -galactosamine (D-GalN) induced hepatotoxicity in albino rats. The hepatoprotective effect of ethyl acetate extract of M. oleifera leaves at doses of 150mg/kg, 200mg/kg and 250 mg/kg body weight respectively per orally was evaluated by inducing hepatotoxicity with D-Galn at a dose of 300mg/kg body weight intraperitoneally and using Silymarin 100mg/kg per orally as the standard reference drug. The hepatoprotective activity was monitored biochemically by various biochemical assays (serum SGOT, SGPT, ALP, LDH, γGT, total and direct bilirubin) using a Sys 200 pro autoanalyzer and histopathological examinations of the collected liver were carried out. The extract exhibited significant (p < 0.05) hepatoprotective effect in a dose-dependent manner in D-GalN intoxicated albino rats. Standard drug, silymarin (100mg/kg) also significantly reversed the hepatotoxicity. The histopathological findings were supportive of the biochemical findings which highlighted the protective role of Moringa oleifera against hepatic injury induced by D- GalN.
Article Information
19
3352-3359
1904 KB
9
English
IJPSR
Laishram Devita Devi *, Laishram Babycha, R. K. Vidyabati Devi and Sunita Haobam
Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Imphal East, Manipur, India.
devitalaishram10@gmail.com
05 June 2025
08 July 2025
10 July 2025
10.13040/IJPSR.0975-8232.16(12).3352-59
01 December 2025
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