EMERGING TRENDS IN IN-SITU GELLING NANOTECHNOLOGY FOR OCULAR DRUG DELIVERY

The most serious health issues facing the world today are blindness and vision impairment, which have a significant financial and societal cost. Delivering drugs to specific ocular regions is challenging due to the eye anatomical and physiological elimination mechanisms. When drugs are instilled to the eye using traditional delivery systems, their ocular bioavailability is low. These methods can avoid the ocular obstacles that currently limit the effectiveness of conventional therapies. They can also provide a longer-lasting release of the drug, which reduces dosing frequency and improves patient compliance. Drug delivery techniques based on nanotechnology, including micelles, nanosuspensions, nanoparticles, colloidal emulsions, niosomes and cubosomes offer efficient alternatives to conventional eye therapy. These devices are being used to study treatments for conditions affecting the anterior portion of the eye. The several delivery methods based on nanotechnology that are being researched for the treatment of anterior eye disorders are covered in this paper. The present and promising advancements in in-situ gelling as a means of delivering ocular medication were reviewed and summarized in this paper.