IN-VITRO ANTI-INFLAMMATORY ASSESSMENT OF PLANT-DERIVED NATURAL PRODUCTS AS NOVEL DRUG LEADS
AbstractInflammation is considered as a biological response of the human body that counteracts harmful stimuli by activating different anti-inflammatory cellular signaling pathways to maintain good health and well-being. However, the persistence of inflammation in tissue or organ may lead to adverse chronic inflammatory responses resulting in diseases of chronic nature. Non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and immune suppressants are widely used to minimize adverse responses mediated by inflammation. However, the development of detrimental side effects in long-term usage of these drugs has directed the scientific community towards identifying novel and safe plant-based anti-inflammatory agents. The plant-based novel drug discoveries involve in a wide range of preliminary in-vitro assessment methods. This article review the methods, principles, advantages and limitations of different assay procedures that have been widely used in evaluating anti-inflammatory properties. Aim of this review is to provide a guidance for identifying plant derived natural compounds with potential anti-inflammatory effects.
Article Information
18
198-212
555 KB
11
English
IJPSR
Prathitha Chathuri Tenne, Prasanna Galhena, Anura Dissanayake, Dinithi Peiris, Ajit Abeysekera and Chayanika Padumadasa *
Department of Chemistry, University of Sri Jayewardenepura, Sri Lanka.
chayanikapadumadasa@yahoo.com
06 August 2024
11 November 2025
20 November 2025
10.13040/IJPSR.0975-8232.17(1).198-12
01 January 2026
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