A CLINICAL INVESTIGATION ON THE THERAPEUTIC OUTCOMES OF DIURETICS IN DIABETIC PATIENTS WITH COMORBIDITIES

This prospective observational study measures the prevalence of electrolyte disturbances in diabetes mellitus patients with co-morbidities who were under diuretic therapy. Further the levels of serum electrolytes and fasting blood glucose the patients were correlated with each other. Of all the 120 patients, 33.33% (40) were having diabetes with chronic kidney disease, 56.67% (68) were having diabetes with cardiovascular disease, 10% (12) were having diabetes with both comorbidities. Among them, 2.5% (3) were having hyperkalaemia, 14.17% (17) were having hypokalaemia, 10.83% (13) were having hyponatraemia, 5% (6) were having hypercalcaemia, 10% (12) were having hypocalcaemia, 2.5% (3) were having hyperchloraemia, 13.33% (16) were having hypochloraemia and 5.84% (7) were having hypomagnesaemia. 35.83% (43) were having no electrolyte disturbances. In diabetes mellitus patients with chronic kidney disease under furosemide, a negative correlation was observed between serum potassium and fasting blood glucose. A negative correlation was observed between serum potassium and fasting blood glucose. In diabetes mellitus patients with cardiovascular disease, on furosemide, a negative correlation was observed between serum potassium and fasting blood glucose. In patients on torasemide, a negative correlation was observed between serum potassium and fasting blood glucose. In patients on hydrochlorothiazide, a negative correlation was observed between serum potassium and fasting blood glucose. In patients on furosemide and spironolactone, a negative correlation was observed between serum sodium and fasting blood glucose. There was a varying spectrum in the relationship between the serum electrolytes and fasting blood glucose in various classes of diabetes mellitus patients.