OCULAR DRUG DELIVERY: INSIGHTS TO BARRIERS AND STRATEGIC APPROACHES FOR ENHANCED THERAPEUTIC EFFICACY
AbstractOphthalmic drug delivery is a highly complicated task to actively target the internal structures of the eye. The eye being a very delicate organ is protected by multiple physiological barriers which include corneal epithelium, blood ocular -barriers, conjunctiva etc. which limits the transport of lipophilic and hydrophilic molecules across the various layers of the eye making it difficult to target the posterior areas of the eye. Although these regions can be accessed by interventional approaches like intravitreal injections and mechanical modifications like iontophoresis but are associated with physiological restrictions and patient discomfort. This review analyses all the barriers to ocular drug delivery along with different strategies to overcome these barriers including all the nanoparticulate strategies of drug delivery which aim to enhance permeation and bioavailability to ocular region. These methods accurately target the internal structures, practical to implement and are patient compliant. The review also gives a short information about the application of periocular route in drug delivery along with its significance in traditional medicine.
Article Information
6
1107-1121
848 KB
5
English
IJPSR
Hrithik Satish Revankar *, Omkar Parab and Shilpa Bhilegaonkar
Department of Pharmaceutics, PES Rajaram and Tarabai Bandekar College of Pharmacy Farmagudi, Ponda, Goa, India.
hrithikrevankar2000@gmail.com
22 October 2025
21 November 2025
17 December 2025
10.13040/IJPSR.0975-8232.17(4).1107-21
01 April 2026
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