ROLE OF GELUCIRE IN SOLUBILITY ENHANCEMENT: A COMPREHENSIVE REVIEW
AbstractThe aim of this article is to provide a comprehensive review of Gelucire as an effective excipient for improving the solubility and bioavailability of poorly water-soluble drugs. Gelucire, a family of lipid-based, amphiphilic excipients, has emerged as a valuable carrier for enhancing the solubility and dissolution of poorly soluble drugs. Gelucire combines hydrophilic polyethylene glycol esters and lipophilic glycerides, enabling self-emulsification, improved wettability, and formation of stable solid dispersions. Different types of Gelucire are used in oral and topical formulations to improve drug release profiles, bioavailability, and stability. This review discusses Gelucire’s chemical nature, hydration behaviour, and applications in solid dispersions for solubility enhancement. There are other various solubility improvement methods like chemical, physical, and advanced techniques with an emphasis on solid dispersions and their preparation, advantages, and challenges. Combining Gelucire with solid dispersion techniques provides a promising approach for improving drug delivery and therapeutic efficacy of poorly soluble drugs.
Article Information
8
1129-1135
496 KB
7
English
IJPSR
Trapti Saxena *, Rohini Mirdhodie, Karan Yadav, Sheik Shaheen, Gajarla Sowmya Varma and Mohd Mohsin
Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, India.
trapti.saxena@gprcp.ac.in
03 November 2025
15 December 2025
31 December 2025
10.13040/IJPSR.0975-8232.17(4).1129-35
01 April 2026
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