FORMULATION AND EVALUATION OF ANTIARTHRITIC HERBAL TOPICAL GEL

Objective: Curcuma longa and Boswellia serrata are traditional medicinal plants that have antiarthritic activity. The present research is intended to formulate a novel antiarthritic topical gel from the extract of Curcuma longa and Boswellia serrata which will increase patient compliance and stability as compared to the conventional dosage form. Material and Method: In this investigation, we created an antiarthritic herbal topical gel by combining carbopol 934 and other excipients with the methanolic extracts of Curcuma longa and Boswellia serrata in varying concentrations. For compatibility study, FTIR study would be done. Evaluation of antiarthritic gel performed by using different tests likes, pH, viscosity, spreadability, extrudability, stability, inhibition of albumin denaturation and in-vitro drug diffusion study. Result and Discussion: As a result, the formulation’s physiochemical characteristics, in-vitro antiarthritic efficacy, and stability analysis (stable even after 30 days) were assessed. Every herbal gel formulation with a pH of 5–7 had favorable outcomes for physiochemical measures. Out of all the formulations, batch no 2 exhibited superior release characteristics (79.8%) in comparison to the other formulated batches. The drug release profile of batch 2 showed excellent results. Conclusion: This is the first study on the scientific evaluation of methanolic extracts of Curcuma longa and Boswellia serrata as a gel for antiarthritic activity. Thus, this study reveals in-vitro drug release; their methanolic extracts may be formulated as antiarthritic topical gel with satisfactory physicochemical parameters.