GRAPTOPHYLLUM PICTUM RESTORES IN THREE DAYS HAEMATOLOGIC PARAMETERS AFTER PHENYLHYDRAZINE-INDUCED ANEMIA OF INFLAMMATION IN WISTAR RATS

Graptophyllum pictum (GP) is used to treat anemiain some traditional communities. To understand this practice, we had prepared GP tea leaves for the management of phenylhydrazine-induced anemia in rats. An experimental protocol was built with six groups of six rats each. Rats in normal group were fed with standard food and water ad libitum. The rest of rats received an intraperitoneal injection of 40 mg/kg of phenylhydrazine for two days to induce anemia. The GP tea leaves (GPTL) had an extraction percentage of 40.8% and contained: ron (32.89 mg/100 g dry material (DM)), carotenoids (649.01 mg/100g DM), phytates (0.22 mg/100g DM) and oxalates (3.21 mg/100g DM For the in-vivo experiment, intraperitoneal injection of phenylhydrazine leads to decreases: hemoglobin, hematocrit, red blood cells, MCH, MCHC; increases in white blood cells and MCV threshold in anemic rats was observed. After 3 days feeding period of rats with 210 mg / kg of (GPTL) or 0.3mg / kg of Ranferon^®, a restoration of all the parameters mentioned was observed. (GPTL)  restored of hematological parameters in the case of anemia compared to Ranferon^®, a pharmaceutical drug. Thus, GPTL exhibits therapeutic anti-anemia effects and could be used as a natural alternative to treat anemia of inflammation.