PRODUCTION OF AN ANTI-GASTRIC ULCER SYRUP FROM KHAYA GRANDIFOLIOLA BARK.
AbstractGastric ulcers (GU) represent a world prevalence of 5-10% and a 10.4% prevalence in Cameroon. The frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) is one of the major causes. The effective treatments available are expensive and have serious side effects. Treating GU with medicinal plants could be a safer alternative solution. In this work, we formulated an anti-ulcer syrup using the aqueous extract of Khaya grandifoliola bark (KG). GU was induced in rats by administering orally indomethacin at 5mg/kg for 5 days. A treatment for 5 days with Khaya grandifoliola syrup (12.4 mg/kg), Spathodea campanulata syrup (200 mg/kg) and misoprostol (100 µg/kg), a reference pharmaceutical drug was given. KG syrup quality control test gave a pH of 5.18 and a density of 1.28. This syrup caused a 79.72% reduction of ulceration surface area and a significant increase in mucus mass of 85.29% (p < 0.05) compared to the Ulcer control. Biochemical parameters revealed a significant increase in antioxidants (65.38% GSH; 45.65% Catalase at p< 0.05) and a decrease of 76.87% in malondialdehyde after indomethacin induction. The formulated KG syrup exhibited therapeutic anti-ulcer effects and could be used as a natural alternative to treat GU.
Article Information
11
1797-1802
868 KB
8
English
IJPSR
A. Y. Mely Keabou, F. Kouoh Elombo *, E. Chieugo Ngoune, F. Tatene Dok-koimbi, Kemmegne Sandrine, Frederic Nico Njayou and P. Moundipa Fewo
University of Yaoundé I, Faculty of Sciences -Department of Biochemistry, Laboratory of Pharmacology and Toxicology, 812 Yaoundé, Cameroon.
ferdinand.kouoh@facsciences-uy1.cm
31 December 2025
01 March 2026
15 March 2026
10.13040/IJPSR.0975-8232.17(6).1797-02
01 June 2026
Download