ANTI INFLAMMATORY AND ANALGESIC ACTIVITIES OF SIVA NAMA RASAM IN RODENT MODELS

Siva Nama Rasam (SNR) is a traditional Siddha herbo-mineral formulation used to manage pain and inflammation. The present study evaluated its anti-inflammatory and analgesic activities in rodent models. Anti-inflammatory activity was assessed in Wistar albino rats using carrageenan-induced paw edema, while analgesic activity was evaluated in Swiss albino mice using the hot plate test. Animals were divided into control, standard, and three SNR treatment groups at low, mid, and high doses. In the carrageenan-induced paw edema model, high-dose SNR (18 mg/kg) significantly reduced paw volume, with maximum inhibition of 93.36% at 5 hours (P < 0.001), comparable to indomethacin (95.58%). Mid-dose SNR (15 mg/kg) showed 80.09% inhibition (P < 0.001), while low-dose (12 mg/kg) achieved 27.88% inhibition. In the hot plate test, high-dose (25 mg/kg) SNR increased reaction time by 71.80% at 120 minutes (P < 0.001), mid-dose (21 mg/kg) by 49.29% (P < 0.001), and low-dose (17 mg/kg) by 20.33% (P < 0.01), compared to control, whereas pentazocine produced 99.04% increase. Results indicate a clear dose-dependent response for both anti-inflammatory and analgesic effects. The herbo-mineral combination in SNR likely contributes to its pharmacological efficacy. These findings support the traditional use of SNR for managing pain and inflammation and provide a scientific basis for further mechanistic and clinical studies.