FORMULATION AND EVALUATION OF RESVERATROL LOADED NANOGEL FOR ONYCHOMYCOSIS
AbstractNail plate disorders account for 10% of all dermatological disorders having an impact on 20-25% of population worldwide. Nail bed infections are difficult to treat due to shorter nail residence time of topically applied formulation and unavailability of novel formulations in the market for antimicrobial drug. Increased occurrence of onychomycosis in recent times and because of involvement of occupation, socio-economic status, climate, gender, age and genetic and immune factors it is need of hour to explore the newer formulation with better efficacy. The goal of this study was to use the topical nanoemulsion in gel form for onychomycosis. As, topically applied product is more acceptable than oral product but topically applied product have its own disadvantages. To overcome those nanoemulsion in gel form was prepared. Nanoemulsion was developed using low energy emulsification technique. Nanoemulsion was found to have drug content of 98.03±0.265, globule size 230±0.2 and zeta potential of -0.3mV, converted to a gel using apt polymer. Nanogel thus formed showed better permeation through hoof nail and was having antifungal effect against the required microbes.
Article Information
749 KB
2547-2552
749 KB
7
English
IJPSR
Kanishka Lakhmani * and Rita Lala
Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Colaba, Mumbai, Maharashtra, India.
deepsshikha.s@gmail.com
29 June 2026
, 17 July 2026
20 July 2026
10.13040/IJPSR.0975-8232.17(8).2547-52
01 August 2026
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