THERAPEUTIC POTENTIAL OF TRYUSHNADI MANDURA IN IRON-DEFICIENCY ANEMIA: A REVIEW

Background: Iron deficiency anemia (IDA) is a major global health problem, especially affecting children, women, and pregnant females. In Ayurveda, IDA can be correlated with Pandu Roga, which is associated with impaired digestion (Mandagni) and defective formation of Rakta Dhatu. Iron deficiency anemia (IDA) is the most frequent hematological disorder in children, with an incidence in industrialized countries of 20.1% between 0 and 4 years of age and 5.9% between 5 and 14 years (39 and 48.1% in developing countries). Objective: To critically review the available classical and contemporary evidence on the safety and therapeutic potential of Tryushanadi Mandura in the management of iron deficiency anemia. Material and Mathods: A narrative literature review was conducted using Ayurvedic classical texts such as Chakradutta and electronic databases including PubMed, Google Scholar, and Medline. Relevant articles on formulation components, pharmacological actions, and anemia management were screened. The index, non-index medical journals has also referred to collect information of relevant topic. Results: The formulation contains multiple herbal and mineral ingredients with reported Deepana, Pachana, Rasayana, and Raktavardhaka properties. Individual components demonstrate pharmacological activities such as antioxidant, anti-inflammatory, hepatoprotective, and bioavailability-enhancing effects. However, there is limited direct clinical evidence specifically evaluating Tryushanadi Mandura in IDA. Conclusion: Tryushanadi Mandura shows potential as a supportive formulation in IDA management based on classical rationale and pharmacological properties. However, current evidence is insufficient to conclusively establish its clinical safety and efficacy. Well-designed clinical trials are required.