EFFICIENT VOLTAMMETRIC DETERMINATION OF NIFEDIPINE AT PENCIL GRAPHITE BLEND PASTE ELECTRODE
AbstractPencil graphite electrodes were quite useful in voltammetric studies of wide range of organic compounds with biological and industrial significance. In the present research, HB pencil graphite paste electrode with 15% pencil 8B grade was fabricated. Cyclic voltammetry was used to investigate the electrochemical reduction mechanism of nifedipine at the electrode. The peak due to 4e- and 4H+ reduction of 2-nitro group of the drug to hydroxyl amine is selected for the voltammetric method development. The pencil graphite blend paste electrode produced good and consistent reduction peaks of nifedipine by differential pulse voltammetry. The optimisation of pH, scan rate, accumulation time and potential and other parameters was carried out using DPV peak signals. A linear range of 10 – 100 nM for nifedipine was obtained with equation Ip(μA) = 0.098C(nM)+4.309 (correlation coefficient, R2 = 0.999) and detection limits of 6.0 nM and quantitation limits of 20 nM. By the present method, recoveries values are obtained in the range of 97.0-101.0 % for nifedipine tablets with RSD values ranging from 2.5-3.8%.
Article Information
15
2715-2720
1538 KB
5
English
IJPSR
Y. Madhu Kiran, M. Sunil Kumar and N. Y. Sreedhar *
Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
nyschem01@gmail.com
23 April 2026
23 June 2026
25 June 2026
10.13040/IJPSR.0975-8232.17(9).2715-20
01 September 2026
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