DEVELOPMENT AND APPLICATION OF DIFFERENCE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FEBUXOSTAT IN TABLETS
AbstractA simple, rapid, sensitive and cost effective difference spectrophotometric method have been developed for the determination of Febuxostat in its tablet dosage form. The method is based on the induced spectral changes upon changing the pH of the medium that differ in their UV spectra. Difference spectrum, obtained by keeping Febuxostat in 0.1N NaOH in reference cell and same in 0.1N HCl in sample cell, showed two characteristic peaks at 260nm and 315nm with positive and negative absorbance respectively and viceversa. Difference of absorbance between these two maxima was calculated to find out the amplitude, which was plotted against concentration. The calibration curve is linear over the concentration range of 5-25 µg/ml (r2 = 0.999), with a detection limit of 0.58µg/ml. The method was successfully applied to the commercial pharmaceutical drug without interference from common ingredient accompanying the drug along with its dissolution profile and very cost effective as its prevents the use of hazardous and costly organic solvents
Article Information
10
1621-1624
566KB
2009
English
IJPSR
M. Sheth*, S. Joshi and M. Patel
Pharmaceutical Analysis and Quality Assurance Department, K.B. Raval College of Pharmacy, Shertha, AT-Post. Kasturinagar, B/h. Iffco Township, Dist.-Gandhinagar-382 423, Gujarat, India
26 January, 2012
26 April, 2012
14 May, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(6).1621-24
01 June, 2012
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