AN APPROACH TO INCREASE THE SOLUBILITY OF RIFAMPICIN BY SOLID DISPERSION TECHNIQUE

Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poorly water soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Most of the drugs are weakly acidic and weakly basic with poor aqueous solubility. Hence various techniques are used for the improvement of the solubility of poorly water-soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co‐solvency, micellar solubilization, hydrotropy etc. The purpose of this work was to describe the enhance solubility of rifampicin by using solid dispersion technique and Physical mixture with PEG6000. Here drug and carrier ratio 1:1, 1:2, 1:3 and 1:10 respectively. The prepared samples were evaluated by SEM, Drug content, In-vitro studies, Wettability and Solubility, IR studies, Angle of repose. In-vitro drug release showed fast and complete release over a period of 2hrs in pH7.4 release profile of solid dispersion (SD 10) were compared with pure drug and physical mixture. It was confirmed that no interaction between drug and polymers in the formulated solid dispersions by IR Spectra.