ANTI-DIABETIC EFFECTS OF ECLIPTA ALBA ON ALLOXAN-INDUCED DIABETIC MICE

The aim of the present study was to investigate the effects of Eclipta alba leaves extract on the biochemical parameters in alloxan induced diabetic Swiss albino mice. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 135 mg/kg body weight. Ethanolic extracts of E. alba leaves at dose of 200 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD₅₀ value. Our studies was extended to include the effect of the tested doses on different biochemical parameters including serum glucose concentration, transaminases and phasphatse activities, total protein, albumin, urea, uric acid, and creatinine levels in serum. In diabetic mice, serum glucose concentration, transaminases and phasphatse activities, urea, uric acid and creatinine levels were significantly increased but level of serum total protein and albumin were decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of E. alba leaves (200 mg/kg b. wt.), on comparison with diabetic group showed a significant decrease in transaminases and phasphatse activities, urea, uric acid and creatinine level whereas, the serum total protein and albumin levels got increased as compared to diabetic mice. The results suggested that ethanolic extract of E. alba leaves possesses protective effect against alloxan induced diabetic mice.