ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF THIAZOLIDINEDIONE DERIVATIVES

The main aim of the present study was to synthesize new leads with potential antibacterial and antioxidant activities. As a part of systematic investigation of synthesis and biological activity, some of the new thiazoldinedione compounds 5a-e were prepared and screened for their antibacterial and antioxidant activities. The antibacterial evaluation of newly synthesized compounds was carried out by cup-plate method. Antimicrobial activity results revealed that compound 5a showed promising activity against bacteria Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa, 5e was found to be more active aganist Proteus vulgaris. The antioxidant activity was performed by using free radical scavenging activity by DPPH (1, 1-diphenyl-2-picryl-hydrazil) assay method and Ferric ion reduction method, ascorbic acid was used as reference standard. All the tested derivatives show antioxidant activity but compound 5c and 5d show promising antioxidant activity concentration at 50μg /ml and can be further studied with modifications. Some novel thiazolidinediones derivatives 5(a–e) were synthesized by reacting hydrazine hydrate in ethanol to form hydrazinecarboxylicacid [4-(2, 4-Dioxo-thiazolidin-5-ylidenemethyl)-phenyl-esterand substituted derivatives were formed by further reaction. The target molecules have been characterized by IR, ¹H NMR, ¹³C NMR, and mass spectral studies.