VISIBLE SPECTROSCOPIC DETERMINATION OF FAROPENEM SODIUM IN PHARMACEUTICAL DOSAGE FORM
AbstractTwo simple, precise, accurate and economical visible spectrophotometric methods were developed for the determination of faropenem in bulk and in tablet dosage forms have been described. The method A was based on the formation of green color complex with Potassium ferri-cyanide in the presence of Ferric chloride, which show maximum absorbance (λ max) at 745nm.The method B is based on the reduction of ferric ion into ferrous ion by the drug in the presence of Ferric ammonium sulphate-1, 10-phenanthroline to form a highly stable Orange red colourferrion complex measured at 511 nm. Mean assays of method A and B was found to be 99.9% and 99.4 % respectively. LOD and LOQ of method A was found to be 2.22 μg/ml and 7.44 μg/ml respectively and for method B it was 7.88 and 26.11 μg/ml.The results of analysis for both the methods have been validated statistically as per ICH guidelines. The proposed methods were simple, sensitive and economical for the quantitative determination of faropenem and were successfully employed for the estimation in pure and in tablet dosage forms.
Article Information
55
437-441
514KB
1864
English
IJPSR
Iffath Rizwana , K. Vanitha Prakash *, G. Krishna Mohan
Professor and Principal, SSJ College of Pharmacy, Vattinagula Pally, Gandipet, Hyderabad -500075, Rangareddy Dist. A.P. India.
vanithaprakashssj@gmail.com
02 June 2014
12 August, 2014
22 September, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.6(1).437-41
01 January, 2015
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