MOLECULAR DOCKING OF PHYTOCHEMICAL AS FTSZ CELL DIVISION PROTEIN INHIBITOR IN MYCOBACTERIUM TUBERCULOSIS

Mycobacterium tuberculosis is the causal agent of tuberculosis which is an infectious disease responsible for more than 2 million deaths per annum worldwide, mainly in developing countries. Cell division of this microbe is very crucial for propagation. Filamenting temperature sensitive mutant Z (FtsZ) is very important player that seems to assemble into a dynamic ring (Z- ring) on the inner surface of the cytoplasmic membrane which involved in stabilizing Z-rings at the place where the division occurs and the formation of the ring is the signal for septation to begin. To control this disease researchers have investigated many naturally occurring bioactive molecules from different medicinal plants. In the present docking study, we screened a total of fifty-one different bioactive molecules found in three medicinal plants namely Justicia adhatoda, Abrus precatoriu sand Dracaena angustifolia to determine the inhibition against M. tuberculosis FtsZ cell divisional protein. No inhibitory effect was observed for the molecule found in D. angustifolia on the other hand, three compounds namely abrectorin, precatorine and gallic acid of A. precatorius and one compound namely vasicine of J. adhatoda showed inhibition. Among the four dock compounds, only abrectorin showed very good Moldock and Rerank Score (-121.394KJmol^-1 and -108.71KJmol^-1) with H-Bond (-9.03613KJmol^-1). From, this investigation it could be contemplated that the plant species A. precatorius and J. adhatoda may be the good sources of FtsZ protein inhibitor. Validation of the compound in wet laboratory will help to explore its usability.