MICROWAVE ASSISTED SYNTHESIS & QSAR STUDY OF SOME NOVEL PYRAZOLYL THIAZINE DERIVATIVES
AbstractThis work involves synthesis of pyrazolyl thiazine derivatives from different chalcones [1(a-b)] synthesized from substituted acetophenones and different aromatic aldehydes in basic medium by Claisen-Schmidt reaction. These chalcones [1(a-b)] on condensation with different hydrazides [2(a-b)] and isothiocyanates [3(a-b)] when irradiated with microwaves (20%, 140watts) in scientific microwave oven, give different 2-phenyl-2,5-dihydro-pyrazole-1-carbothioic acid phenyl amide derivatives [4(a-g)] which on further MW assisted condensation with substituted acetophenones and different aromatic aldehydes, furnish pyrazolyl thiazine derivatives [7(a-j)]. Library of such pyrazolyl thiazine derivatives has been generated and the structures were subjected to PASS for their probabilities of being active biologically. QSAR study of the library was done to find out most active Molecules.
Article Information
64
5556-5563
711KB
1943
English
Ijpsr
V. S. Kapase, S. S. Khot, S. A. Kenawade and S. R. Dhongade*
Research Laboratory in Heterocyclic Chemistry, Devchand College, Arjunnagar, Maharastra India
savitadesai2010@gmail.com
22 April, 2014
15 June, 2014
19 July, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5556-63
01 December, 2014
Download